abstract：:Amyloid beta-peptide is produced by the cleavage of amyloid precursor protein by two secretases, a β-secretase, beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) and a γ-secretase. It has been hypothesised that partial inhibition of BACE1 in individuals with a high risk of developing Alzheimer's disease ma...

journal_title：Genes

authors： Chakravarthy M,Veedu RN

更新日期：2019-09-12 00:00:00

abstract：:The multiple organellar RNA editing factors (MORF) gene family plays a key role in organelle RNA editing in flowering plants. MORF genes expressions are also affected by abiotic stress. Although seven OsMORF genes have been identified in rice, few reports have been published on their expression patterns in different t...

journal_title：Genes

authors： Zhang Q,Shen L,Ren D,Hu J,Chen G,Zhu L,Gao Z,Zhang G,Guo L,Zeng D,Qian Q

更新日期：2019-09-10 00:00:00

abstract：:The Sichuan partridge (Arborophila rufipectus, Phasianidae, Galliformes) is distributed in south-west China, and classified as endangered grade. To examine the evolution and genomic features of Sichuan partridge, we de novo assembled the Sichuan partridge reference genome. The final draft assembly consisted of approxi...

journal_title：Genes

authors： Zhou C,Tu H,Yu H,Zheng S,Dai B,Price M,Wu Y,Yang N,Yue B,Meng Y

更新日期：2019-09-05 00:00:00

abstract：:Mutations affecting the Retinitis Pigmentosa GTPase Regulator (RPGR) gene are the commonest cause of X-linked and recessive retinitis pigmentosa (RP), accounting for 10%-20% of all cases of RP. The phenotype is one of the most severe amongst all causes of RP, characteristic for its early onset and rapid progression to...

journal_title：Genes

authors： Cehajic Kapetanovic J,McClements ME,Martinez-Fernandez de la Camara C,MacLaren RE

更新日期：2019-09-04 00:00:00

abstract：:Use of genetic markers and genomic prediction might improve genetic gain for quality traits in wheat breeding programs. Here, flour yield and Alveograph quality traits were inspected in 635 F6 winter wheat breeding lines from two breeding cycles. Genome-wide association studies revealed single nucleotide polymorphisms...

journal_title：Genes

authors： Kristensen PS,Jensen J,Andersen JR,Guzmán C,Orabi J,Jahoor A

更新日期：2019-08-31 00:00:00

abstract：:Plants grown under highly variable natural light regimes differ strongly from plants grown under constant light (CL) regimes. Plant phenotype and adaptation responses are important for plant biomass and fitness. However, the underlying regulatory mechanisms are still poorly understood, particularly from a transcriptio...

journal_title：Genes

authors： Ding J,Zhao J,Pan T,Xi L,Zhang J,Zou Z

更新日期：2019-08-29 00:00:00

abstract：:In this contribution, the aspects of reptile and amphibian speciation that emerged from research performed over the past decade are reviewed. First, this study assesses how patterns and processes of speciation depend on knowing the taxonomy of the group in question, and discuss how integrative taxonomy has contributed...

journal_title：Genes

authors： Wollenberg Valero KC,Marshall JC,Bastiaans E,Caccone A,Camargo A,Morando M,Niemiller ML,Pabijan M,Russello MA,Sinervo B,Werneck FP,Sites JW,Jr.,Wiens JJ,Steinfartz S

更新日期：2019-08-26 00:00:00

abstract：:The 2019 "Personal Genomes: Accessing, Sharing and Interpretation" conference (Hinxton, UK, 11-12 April 2019) brought together geneticists, bioinformaticians, clinicians and ethicists to promote openness and ethical sharing of personal genome data while protecting the privacy of individuals. The talks at the conferenc...

journal_title：Genes

authors： Rubin IR,Glusman G

更新日期：2019-08-25 00:00:00

abstract：:RabGTPase activating proteins (RabGAP) are responsible for directing the deactivation of vesicular trafficking master regulators associated to plant development, the RabGTPase proteins. Recently, RabGAPs were identified in Arabidopsis and rice, but studies were not yet reported in tomato. Herein, we identified 24 RabG...

journal_title：Genes

authors： Madrid-Espinoza J,Salinas-Cornejo J,Ruiz-Lara S

更新日期：2019-08-23 00:00:00

abstract：:Brycon is an important group of Neotropical fish and the principal genus of the family Bryconidae, with 44 valid species that are found in some Central American rivers and practically all the major hydrographic basins of South America. These fish are medium to large in size, migratory, omnivorous, important seed dispe...

journal_title：Genes

authors： Arruda PSS,Ferreira DC,Oliveira C,Venere PC

更新日期：2019-08-23 00:00:00

abstract：:Cancer is the second deadliest disease listed by the WHO. One of the major causes of cancer disease is tobacco and consumption possibly due to its main component, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). A plethora of studies have been conducted in the past aiming to decipher the association of NNK with o...

journal_title：Genes

authors： Anukriti.,Dhasmana A,Uniyal S,Somvanshi P,Bhardwaj U,Gupta M,Haque S,Lohani M,Kumar D,Ruokolainen J,Kesari KK

更新日期：2019-07-26 00:00:00

abstract：BACKGROUND:HER2 (human epidermal growth factor 2)-positive breast cancer is an aggressive type of breast cancer characterized by the overexpression of the receptor-type protein tyrosine kinase HER2 or amplification of the HER2 gene. It is commonly treated by the drug trastuzumab (Herceptin), but resistance to its actio...

journal_title：Genes

authors： Buiga P,Elson A,Tabernero L,Schwartz JM

更新日期：2019-07-26 00:00:00

abstract：:Prader-Willi Syndrome Association (USA) monitors the ongoing health and welfare of individuals with Prader-Willi syndrome (PWS) through active communication with members by membership surveys and data registries. Thromboembolism and blood clots have emerged in clinical studies as significant risk factors for injury an...

journal_title：Genes

authors： Manzardo AM,Heinemann J,McManus B,Loker C,Loker J,Butler MG

更新日期：2019-07-19 00:00:00

abstract：:Fat deposition in pigs, which significantly contributes to meat quality, fattening efficiency, reproductive performance, and immunity, is critically affected by preadipocyte adipogenic differentiation. We elucidated adipogenesis in pigs using transcriptome analysis. Preadipocytes from subcutaneous adipose tissue (SAT)...

journal_title：Genes

authors： Zhao X,Chen S,Tan Z,Wang Y,Zhang F,Yang T,Liu Y,Ao H,Xing K,Wang C

更新日期：2019-07-19 00:00:00

abstract：:Xyloglucan endotransglycosylase/hydrolase (XTH) is a cell-wall-modifying enzyme participating in diverse cell morphogenetic processes and adaptation to stress. In this study, 48 XTH genes were identified from two pineapple (Ananas comosus) cultivars ('F153' and 'MD2') and designated Ac(F153)XTH1 to -24 and Ac(MD2)XTH1...

journal_title：Genes

authors： Li Q,Li H,Yin C,Wang X,Jiang Q,Zhang R,Ge F,Chen Y,Yang L

更新日期：2019-07-16 00:00:00

abstract：:Despite recent genetic advances and numerous ongoing therapeutic trials, malignant melanoma remains fatal, and prognostic factors as well as more efficient treatments are needed. The development of such research strongly depends on the availability of appropriate models recapitulating all the features of human melanom...

journal_title：Genes

authors： Prouteau A,André C

更新日期：2019-06-30 00:00:00

abstract：:The anaerobic degradation of benzoate in bacteria involves the benzoyl-CoA central pathway. Azoarcus/Aromatoleum strains are a major group of anaerobic benzoate degraders, and the transcriptional regulation of the bzd genes was extensively studied in Azoarcus sp. CIB. In this work, we show that the bzdR regulatory gen...

journal_title：Genes

authors： Durante-Rodríguez G,Gutiérrez-Del-Arroyo P,Vélez M,Díaz E,Carmona M

更新日期：2019-06-27 00:00:00

abstract：:The spectrum of modern horse populations encompasses populations with a long history of development in isolation and relatively recently formed types. To increase our understanding of the evolutionary history and provide information on how to optimally conserve or improve these populations with varying development and...

journal_title：Genes

authors： Schurink A,Shrestha M,Eriksson S,Bosse M,Bovenhuis H,Back W,Johansson AM,Ducro BJ

更新日期：2019-06-25 00:00:00

abstract：:Pleurotus tuoliensis (Pt) and P. eryngii var. eryngii (Pe) are important edible mushrooms. The epigenetic and gene expression signatures characterizing major developmental transitions in these two mushrooms remain largely unknown. Here, we report global analyses of DNA methylation and gene expression in both mushrooms...

journal_title：Genes

authors： Wen J,Zhang Z,Gong L,Xun H,Li J,Qi B,Wang Q,Li X,Li Y,Liu B

更新日期：2019-06-17 00:00:00

abstract：:Elymus sibiricus, which is a perennial and self-pollinated grass, is the typical species of the genus Elymus, which plays an important role in forage production and ecological restoration. No reports have, so far, systematically described the selection of optimal reference genes for reverse transcriptase quantitative ...

journal_title：Genes

authors： Zhang J,Xie W,Yu X,Zhang Z,Zhao Y,Wang N,Wang Y

更新日期：2019-06-13 00:00:00

abstract：:Terpenoids play important roles in plant defense. Although some terpene synthases have been characterized, terpenoids and their biosynthesis in wheat (Triticumaestivum L.) still remain largely unknown. Here, we describe the identification of a terpene synthase gene in wheat. It encodes a sesquiterpene synthase that ca...

journal_title：Genes

authors： Pu Q,Liang J,Shen Q,Fu J,Pu Z,Liu J,Wang X,Wang Q

更新日期：2019-06-10 00:00:00

abstract：:Spiders often produce multiple types of silk, each with unique properties suiting them to certain tasks and biological functions. Orb-weaver spiders can generate more than six types of silk fibroins, with pyriform silk used to form attachment discs, adhering silk to other surfaces and substances. The unique higher-ord...

journal_title：Genes

authors： Wang K,Wen R,Jia Q,Liu X,Xiao J,Meng Q

更新日期：2019-06-03 00:00:00

abstract：:High-throughput technologies have allowed researchers to obtain genome-wide data from a wide array of experimental model systems. Unfortunately, however, new data generation tends to significantly outpace data re-utilization, and most high throughput datasets are only rarely used in subsequent studies or to generate n...

journal_title：Genes

authors： Halajyan A,Weingart N,Yeahia M,Loza-Coll M

更新日期：2019-06-01 00:00:00

abstract：:Eimeria tenella (E. tenella) is one of the most frequent and pathogenic species of protozoan parasites of the genus Eimeria that exclusively occupies the cecum, exerting a high economic impact on the poultry industry. To investigate differentially expressed genes (DEGs) in the cecal tissue of Jinghai yellow chickens i...

journal_title：Genes

authors： Wang X,Zou W,Yu H,Lin Y,Dai G,Zhang T,Zhang G,Xie K,Wang J,Shi H

更新日期：2019-05-31 00:00:00

abstract：:Dwarfism is a condition defined by low harvest weight in fish, but also results in strange body figures which may have potential for the selective breeding of new ornamental fish strains. The objectives of this study are to reveal the physiological causes of dwarfism and identify the genetic loci controlling this trai...

journal_title：Genes

authors： Shao F,Liu J,Ren M,Li J,Bao H,Wu C

更新日期：2019-05-30 00:00:00

abstract：:While the number of mammalian genome assemblies has proliferated, Y-chromosome assemblies have lagged behind. This discrepancy is caused by biological features of the Y-chromosome, such as its high repeat content, that present challenges to assembly with short-read, next-generation sequencing technologies. Partial Y-c...

journal_title：Genes

authors： Rando HM,Wadlington WH,Johnson JL,Stutchman JT,Trut LN,Farré M,Kukekova AV

更新日期：2019-05-28 00:00:00

abstract：:Salinity is one of the major environment factors that limits the growth of plants and the productivity of crops worldwide. It has been shown that Na+ transporters play a central role in salt tolerance and development of plants. The objective of this study was to identify Na+/H+ antiporter (NHX) genes and investigate t...

journal_title：Genes

authors： Wu GQ,Wang JL,Li SJ

更新日期：2019-05-27 00:00:00

abstract：:Here, we describe the creation of three integration vectors, pPEPX, pPEPY and pPEPZ, for use with the opportunistic human pathogen Streptococcus pneumoniae. The constructed vectors, named PEP for Pneumococcal Engineering Platform (PEP), employ an IPTG-inducible promoter and BglBrick and BglFusion compatible multiple c...

journal_title：Genes

authors： Keller LE,Rueff AS,Kurushima J,Veening JW

更新日期：2019-05-22 00:00:00

abstract：:Hemp is a Pb-tolerant and Pb-accumulating plant and the study of its tolerance mechanisms could facilitate the breeding of hemp with enhanced Pb tolerance and accumulation. In the present study, we took advantage of sequential window acquisition of all theoretical mass spectra (SWATH) technology to study the differenc...

journal_title：Genes

authors： Xia C,Hong L,Yang Y,Yanping X,Xing H,Gang D

更新日期：2019-05-22 00:00:00

abstract：:White coat color in mammals has been selected several times during the domestication process. Numerous dog breeds are fixed for one form of white coat color that involves darkly pigmented skin. The genetic basis of this color, due to the absence of pigment in the hairs, was suggested to correspond to extreme dilution ...

journal_title：Genes

authors： Hédan B,Cadieu E,Botherel N,Dufaure de Citres C,Letko A,Rimbault M,Drögemüller C,Jagannathan V,Derrien T,Schmutz S,Leeb T,André C

更新日期：2019-05-21 00:00:00

abstract：:Intercellular karyotypic variability has been a focus of genetic research for more than 50 years. It has been repeatedly shown that chromosome heterogeneity manifesting as chromosomal mosaicism is associated with a variety of human diseases. Due to the ability of changing dynamically throughout the ontogeny, chromosom...

journal_title：Genes

authors： Iourov IY,Vorsanova SG,Yurov YB,Kutsev SI

更新日期：2019-05-19 00:00:00

abstract：:Droplet digital PCR is the most robust method for absolute nucleic acid quantification. However, RNA is a very versatile molecule and its abundance is tissue-dependent. RNA quantification is dependent on a reference control to estimate the abundance. Additionally, in cancer, many cellular processes are deregulated whi...

journal_title：Genes

authors： Villegas-Ruíz V,Olmos-Valdez K,Castro-López KA,Saucedo-Tepanecatl VE,Ramírez-Chiquito JC,Pérez-López EI,Medina-Vera I,Juárez-Méndez S

更新日期：2019-05-17 00:00:00

abstract：:Histone acts as the core for nucleosomes and is a key protein component of chromatin. Among different histone variants, histone H3 (HH3) variants have been reported to play vital roles in plant development. However, biological information and evolutionary relationships of HH3 genes in cotton remain to be elucidated. T...

journal_title：Genes

authors： Qanmber G,Ali F,Lu L,Mo H,Ma S,Wang Z,Yang Z

更新日期：2019-05-09 00:00:00

abstract：:The central goal of medical genomics is to understand the inherited basis of sequence variation that underlies human physiology, evolution, and disease. Functional association studies currently ignore millions of bases that span each centromeric region and acrocentric short arm. These regions are enriched in long arra...

journal_title：Genes

authors： Miga KH

更新日期：2019-05-08 00:00:00

abstract：:The liver plays a key role in metabolism and affects pig production. However, the functional annotation of noncoding regions of the pig liver remains poorly understood. We revealed the landscape of cis-regulatory elements and their functional characterization in pig liver. We identified 102,373 cis-regulatory elements...

journal_title：Genes

authors： Luan Y,Zhang L,Hu M,Xu Y,Hou Y,Li X,Zhao S,Zhao Y,Li C

更新日期：2019-05-07 00:00:00

abstract：:Tetralin (1,2,3,4-tetrahydonaphthalene) is a recalcitrant compound that consists of an aromatic and an alicyclic ring. It is found in crude oils, produced industrially from naphthalene or anthracene, and widely used as an organic solvent. Its toxicity is due to the alteration of biological membranes by its hydrophobic...

journal_title：Genes

authors： Floriano B,Santero E,Reyes-Ramírez F

更新日期：2019-05-06 00:00:00

abstract：:The Kelpie is a breed developed in Australia for use as a livestock herding dog. It has been proposed that the development of the breed included gene flow from the Australian Dingo (Canis dingo), a canid species present on the Australian continent for around 4000 years. The Kelpie breed is split between working and co...

journal_title：Genes

authors： Chew T,Willet CE,Haase B,Wade CM

更新日期：2019-05-03 00:00:00

abstract：:Each domestic dog breed is characterized by a strict set of physical and behavioral characteristics by which breed members are judged and rewarded in conformation shows. One defining feature of particular interest is the coat, which is comprised of either a double- or single-layer of hair. The top coat contains coarse...

journal_title：Genes

authors： Whitaker DT,Ostrander EA

更新日期：2019-04-26 00:00:00

abstract：:Telomeric repeats, coated by the shelterin complex, prevent inappropriate activation of the DNA damage response at the ends of linear chromosomes. Shelterin has evolved distinct solutions to protect telomeres from different aspects of the DNA damage response. These solutions include formation of t-loops, which can seq...

journal_title：Genes

authors： Doksani Y

更新日期：2019-04-24 00:00:00

abstract：:This article explores the mechanism of miR-194 on the proliferation and apoptosis of Aβ1-42-transduced hippocampal neurons. Aβ1-42-transduced hippocampal neuron model was established by inducing hippocampal neurons with Aβ1-42. MTT assay and flow cytometry were used to detect the viability and apoptosis of hippocampal...

journal_title：Genes

authors： Wang T,Cheng Y,Han H,Liu J,Tian B,Liu X

更新日期：2019-04-21 00:00:00